Novel desvenlafaxine succinate monohydrate crystal and preparation method thereof

The invention relates to a novel esvenlafaxine succinate monohydrate crystal VI. An X-ray powder diffraction pattern of the crystal VI comprises diffraction peaks at angles 2 theta of 5.14 degrees, 10.26 degrees, 13.16 degrees, 14.28 degrees, 16.67 degrees, 19.14 degrees, 20.60 degrees, 23.30 degrees and 25.86 degrees. The invention also relates to a preparation method of the crystal VI. The crystal VI can be prepared easily and has good stability and preparation formability. Compared with crystals I, II and M, the crystal VI has the best tablet yield and can be processed to form a sustained release tablet with a release curve more close to that of a sold preparation. 本发明涉及种琥珀酸去甲文拉法辛水合物的新晶型Ⅵ，所述Ⅵ晶型的X-射线粉末衍射图谱包括以下2θ角所示的衍射峰：5.14°、10.26°、13.16°、14.28°、16.67°、19.14°、20.60°、23.30°和25.86°。本发明还涉及所述晶型Ⅵ的制备方法。本发明Ⅵ晶型易于制备，具有较好的稳定性和制剂成型性，并且相比于晶型Ⅰ、Ⅱ和M，晶型Ⅵ制片收率最优，所制得的缓释片释放曲线更接近市售制剂。