Inhibitor of bTopo I (bacterial toposomerase I) and application of inhibitor

The invention discloses an inhibitor of bTopo I (bacterial toposomerase I) and an application of the inhibitor and belongs to the field of molecular biology. According to the characteristic that bTopo I recognizes a reaction substrate, double-chain nucleotide adopting an unmatched basic group struct...

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Hauptverfasser:	JIANG TAYU, YANG ZHAOQI, ZHONG HANSHI, LIU YUANFA
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLICBEVERAGES MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses an inhibitor of bTopo I (bacterial toposomerase I) and an application of the inhibitor and belongs to the field of molecular biology. According to the characteristic that bTopo I recognizes a reaction substrate, double-chain nucleotide adopting an unmatched basic group structure acts on bTopo I, and a targeted antibacterial effect is realized. Besides, due to the fact that bTopo I and topoisomerase I of mammal animals have different acting mechanisms, novel antibacterial molecules with the double-chain nucleotide adopting the unmatched basic group structure as a basis have an important function on interfering bacteria without influencing host cells and a theoretical basis and a novel development direction are provided for research of antibacterial medicines. 本发明公开了种细菌I型拓扑异构酶的抑制剂及其应用，属于分子生物学领域。本发明利用bTopo I识别反应底物的特点，提出将具有不配对碱基结构的双链核苷酸作用于bTopo I，从而达到靶向性的抑菌效果。另外，由于bTopo I与哺乳类动物的topoisomerase I有不同的作用机制，因此以具有不配对碱基结构的双链核苷酸为基础的新型抗菌分子，具有干扰细菌的重要功能而不影响宿主细胞的特性，为抗菌药物的研发提供理论依据和全新发展方向。