Fused heterocyclic derivatives and methods of use

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and...

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Hauptverfasser: BAUER DAVID, KIM TAE-SEONG, BODE CHRISTIANE M, D AMICO ERIN, BOOKER SHON, BOEZIO ALESSANDRO, POTASHMAN MICHELLE, HARMANGE JEANRISTOPHE, ROMERO KARINA, LIU LONGBIN, COPELAND KATRINA W, HIRAI SATOKO, HUNGATE RANDALL W, PETERSON EMILY A, XI NING, SPRINGER STEPHANIE, CHOQUETTE DEBORAH, SIEGMUND AARON C, STEC MARKIAN, YANG KEVIN, LOHMAN JULIA, ALBRECHT BRIAN K, BELLON STEVEN, NORMAN MARK H, LEWIS RICHARD T
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes. 本发明涉及稠合杂环衍生物及使用方法。选择的化合物有效地用于预防或治疗疾病例如HGF介导的疾病。本发明包括用于预防和治疗涉及癌症等的疾病和其它疾病或病况的新的化合物、类似物、前药及其可药用盐,药物组合物和方法。本发明还涉及制备所述化合物的方法以及用于上述方法的中间体。