Application of salvianolic acid A in preparation of drugs for treating acute kidney injury

The present invention discloses application of salvianolic acid A in the preparation of drugs for treating acute kidney injury and belongs to the technical field of uses of traditional Chinese medicine effective ingredients. It is proved via pharmacodynamic experiments that salvianolic acid A can effectively relieve renal tubular necrosis and renal tubular microvascular endothelial cell injury, improve expression of vascular endothelium growth factors, inhibit the decrease in microvascular density, improve ischemic anoxic extent and thereby relieve rat renal tissue injury due to acute renal injury. Therefore, the salvianolic acid A may be used to prepare drugs for treating acute renal injury, thereby developing new uses of the salvianolic acid A. 本发明公开了种丹酚酸A在制备治疗急性肾损伤药物中的应用，属于中药有效成分的用途技术领域。本发明通过药效学实验证明，丹酚酸A可有效减轻肾小管坏死和肾小管微血管内皮细胞损伤，增加血管内皮生长因子的表达，抑制微血管密度的减少，改善缺血缺氧程度，从而减轻急性肾损伤大鼠肾脏组织损伤。因此，丹酚酸A可以用作制备治疗急性肾损伤药物，从而开辟了丹酚酸A的新用途。