Nintedanib ethanesulfonate crystal

The invention relates to a nintedanib ethanesulfonate crystal. Specifically, the invention relates to a type A crystal of nintedanib diethanesulfonate. The the X-ray powder diffraction spectrum of the nintedanib diethanesulfonate type A crystal provided by the invention is shown by a 2theta value to...

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Bibliographische Detailangaben
Hauptverfasser: ZHU XUEYAN, SUN JIUDE, ZHANG JIASONG, GUO MENG, HU MINGTONG, WANG HUBO
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to a nintedanib ethanesulfonate crystal. Specifically, the invention relates to a type A crystal of nintedanib diethanesulfonate. The the X-ray powder diffraction spectrum of the nintedanib diethanesulfonate type A crystal provided by the invention is shown by a 2theta value to have diffraction peaks at about 14.64, 18.79, 19.31, 20.11, 21.20, 22.45 and 26.71 degrees. The crystal provided by the invention has the characteristics of stable properties, difficult degradation, and no absorption of moisture, and is especially suitable for production of drugs. 本发明涉及尼达尼布乙磺酸盐结晶,具体而言,本发明涉及尼达尼布二乙磺酸盐的A型结晶。本发明的尼达尼布二乙磺酸盐A型结晶,其X-射线粉末衍射光谱用2θ值表示在约14.64、18.79、19.31、20.11、21.20、22.45、26.71°处有衍射峰。本发明的结晶性质稳定,不易降解、不吸潮,特别适合药物生产。