Inflammatory microenvironment responsive nano-drug and preparation method and application thereof

The invention discloses an inflammatory microenvironment responsive nano-drug and a preparation method and application thereof. The nano-drug is composed of a cardiovascular disease prevention medicine, an inflammatory microenvironment responsive carrier material, phospholipids and polyethylene glycol-DSPE, wherein the mass ratio of polyethylene glycol-DSPE to the cardiovascular disease prevention medicine is (0.1:1)-(10:1), the mass ratio of polyethylene glycol-DSPE to the inflammatory microenvironment responsive carrier material is (0.02:1)-(2:1), the mass ratio of polyethylene glycol-DSPE to phospholipids is (0.01:1)-(2:1), and the particle size of the nano-drug ranges from 20 nm to 900 nm. The nano-drug can be used for preparing medicine for preventing and treating atherosclerosis related diseases, intravascular stent restenosis and abdominal aortic aneurysm. The nano-drug has an obvious prevention function on atherosclerosis related diseases, intravascular stent restenosis and abdominal aortic aneurysm.