Benzylphthalazine compound and its preparation method and use
The invention belongs to the field of drug synthesis, relates to a benzylphthalazine compound with a general formula (I) and especially relates to a benzylphthalazine compound containing piperidine, pyrrolidine or azetidine and its preparation method and use in medical science. An in-vitro Hedgehog...
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| creator | ZHAO WEILI LIU YUAN LU XIUHONG BAO XIAOLONG WANG JUAN TAN WENFU PENG YUANQIU YANG JUN DONG XIAOCHUN |
| description | The invention belongs to the field of drug synthesis, relates to a benzylphthalazine compound with a general formula (I) and especially relates to a benzylphthalazine compound containing piperidine, pyrrolidine or azetidine and its preparation method and use in medical science. An in-vitro Hedgehog signal path target gene Gli inhibition activity test proves that the compound has good Hedgehog signal path inhibition activity. The compound can be used for preparation of a Hedgehog signal path inhibitor and an anti-tumor drug.
本发明属药物合成领域，涉及通式(Ⅰ)的苄基酞嗪化合物，尤其涉及种含哌啶或吡咯烷或氮杂环丁烷的苄基酞嗪化合物，及其制备方法和在医学上的应用。本发明的化合物通过体外Hedgehog信号通路中的靶基因Gli抑制活性测试，结果显示，所述的化合物具有良好的Hedgehog信号通路抑制活性，可进步制备Hedgehog信号通路抑制剂和抗肿瘤药物。 |
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本发明属药物合成领域，涉及通式(Ⅰ)的苄基酞嗪化合物，尤其涉及种含哌啶或吡咯烷或氮杂环丁烷的苄基酞嗪化合物，及其制备方法和在医学上的应用。本发明的化合物通过体外Hedgehog信号通路中的靶基因Gli抑制活性测试，结果显示，所述的化合物具有良好的Hedgehog信号通路抑制活性，可进步制备Hedgehog信号通路抑制剂和抗肿瘤药物。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLB1Ss2rqswpyCjJSMxJrMrMS1VIzs8tyC_NS1FIBOLMkmKFgqLUgsSixJLM_DyF3NSSjHyIVGlxKg8Da1piTnEqL5TmZlB0cw1x9tBNLciPTy0uSExOzUstiXf2MzQwtbQwNTYycDQmRg0AZNAwoA</recordid><startdate>20161005</startdate><enddate>20161005</enddate><creator>ZHAO WEILI</creator><creator>LIU YUAN</creator><creator>LU XIUHONG</creator><creator>BAO XIAOLONG</creator><creator>WANG JUAN</creator><creator>TAN WENFU</creator><creator>PENG YUANQIU</creator><creator>YANG JUN</creator><creator>DONG XIAOCHUN</creator><scope>EVB</scope></search><sort><creationdate>20161005</creationdate><title>Benzylphthalazine compound and its preparation method and use</title><author>ZHAO WEILI ; LIU YUAN ; LU XIUHONG ; BAO XIAOLONG ; WANG JUAN ; TAN WENFU ; PENG YUANQIU ; YANG JUN ; DONG XIAOCHUN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN105985320A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2016</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ZHAO WEILI</creatorcontrib><creatorcontrib>LIU YUAN</creatorcontrib><creatorcontrib>LU XIUHONG</creatorcontrib><creatorcontrib>BAO XIAOLONG</creatorcontrib><creatorcontrib>WANG JUAN</creatorcontrib><creatorcontrib>TAN WENFU</creatorcontrib><creatorcontrib>PENG YUANQIU</creatorcontrib><creatorcontrib>YANG JUN</creatorcontrib><creatorcontrib>DONG XIAOCHUN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZHAO WEILI</au><au>LIU YUAN</au><au>LU XIUHONG</au><au>BAO XIAOLONG</au><au>WANG JUAN</au><au>TAN WENFU</au><au>PENG YUANQIU</au><au>YANG JUN</au><au>DONG XIAOCHUN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Benzylphthalazine compound and its preparation method and use</title><date>2016-10-05</date><risdate>2016</risdate><abstract>The invention belongs to the field of drug synthesis, relates to a benzylphthalazine compound with a general formula (I) and especially relates to a benzylphthalazine compound containing piperidine, pyrrolidine or azetidine and its preparation method and use in medical science. An in-vitro Hedgehog signal path target gene Gli inhibition activity test proves that the compound has good Hedgehog signal path inhibition activity. The compound can be used for preparation of a Hedgehog signal path inhibitor and an anti-tumor drug.
本发明属药物合成领域，涉及通式(Ⅰ)的苄基酞嗪化合物，尤其涉及种含哌啶或吡咯烷或氮杂环丁烷的苄基酞嗪化合物，及其制备方法和在医学上的应用。本发明的化合物通过体外Hedgehog信号通路中的靶基因Gli抑制活性测试，结果显示，所述的化合物具有良好的Hedgehog信号通路抑制活性，可进步制备Hedgehog信号通路抑制剂和抗肿瘤药物。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Benzylphthalazine compound and its preparation method and use |
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