Benzylphthalazine compound and its preparation method and use

The invention belongs to the field of drug synthesis, relates to a benzylphthalazine compound with a general formula (I) and especially relates to a benzylphthalazine compound containing piperidine, pyrrolidine or azetidine and its preparation method and use in medical science. An in-vitro Hedgehog signal path target gene Gli inhibition activity test proves that the compound has good Hedgehog signal path inhibition activity. The compound can be used for preparation of a Hedgehog signal path inhibitor and an anti-tumor drug. 本发明属药物合成领域，涉及通式(Ⅰ)的苄基酞嗪化合物，尤其涉及种含哌啶或吡咯烷或氮杂环丁烷的苄基酞嗪化合物，及其制备方法和在医学上的应用。本发明的化合物通过体外Hedgehog信号通路中的靶基因Gli抑制活性测试，结果显示，所述的化合物具有良好的Hedgehog信号通路抑制活性，可进步制备Hedgehog信号通路抑制剂和抗肿瘤药物。