Fenbendazole nano suspension and preparation method thereof

The invention discloses a fenbendazole nano suspension which is composed of, by mass, 2-8% of fenbendazole, 0.5-2% of a suspending agent, 0.05-0.15% of a wetting agent, 0.5-2% of a flocculating agent, 0.05-0.15% of an antibacterial agent and the balanced being water for injection. Compared with the...

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Bibliographische Detailangaben
Hauptverfasser: ZHANG YAOQI, LI YINGAN, ZHANG FENLI, SUN XUEFENG, LIU SANXIA
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a fenbendazole nano suspension which is composed of, by mass, 2-8% of fenbendazole, 0.5-2% of a suspending agent, 0.05-0.15% of a wetting agent, 0.5-2% of a flocculating agent, 0.05-0.15% of an antibacterial agent and the balanced being water for injection. Compared with the prior art, the fenbendazole is processed into the nano suspension, so that saturated solubility, dissolving rate and mucous membrane adhesion are improved, a problem of low bioavailability of the medicine is overcome and effectiveness, safety and stability of the medicine are improved. The preparation method and formula in the invention are simple. The fenbendazole nano suspension has uniform particle size distribution, is easy to apply and is suitable for industrial production. The nano suspension has excellent stability, improves solubility and oral-taking bioavailability of fenbendazole, is reduced in toxic and side effects and has excellent practical value and application prospect. 本发明公开了种芬苯达唑纳米混悬剂,由以下质量分数的组分组成