Enzymatic process for the regioselective manufacturing of N-Fmoc-doxorubicin-14-O-dicarboxylic acid mono esters

Enzymatic process for the regioselective manufacturing of N-Fmoc-doxorubicin-14-O-dicarboxylic acid mono esters

The present invention describes a process for the selective synthesis of N -Fmoc-doxorubicin-14- O -dicarboxylic acid mono ester derivatives starting from N -Fmoc-doxorubicin using lipase enzymes and bis-acyl donor compounds such as dicarboxylic acids or anhydrides. 本发明描述起始自N-Fmoc-多柔比星、用脂酶和二酰基供体化合物比...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MATTHIAS GERLACH, TILMANN SCHUSTER, FALK SCHUCH
Format: Patent
Sprache:chi ; eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The present invention describes a process for the selective synthesis of N -Fmoc-doxorubicin-14- O -dicarboxylic acid mono ester derivatives starting from N -Fmoc-doxorubicin using lipase enzymes and bis-acyl donor compounds such as dicarboxylic acids or anhydrides. 本发明描述起始自N-Fmoc-多柔比星、用脂酶和二酰基供体化合物比如二羧酸或酸酐来选择性合成N-Fmoc-多柔比星-14-O-二羧酸单酯衍生物的方法。