High-purity 2-(3, 5-dimethylphenyl)-6-isobutyl quinoline synthesis method
The invention discloses a high-purity 2-(3, 5-dimethylphenyl)-6-isobutyl quinoline synthesis method. The method comprises S1, preparing 6-isobutyl quinoline as a first intermediate, S2, preparing 2-(3, 5-dimethylphenyl)-6-isobutyl-1, 2-dihydro-quinoline as a second intermediate, S3, dissolving the 2...
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Zusammenfassung: | The invention discloses a high-purity 2-(3, 5-dimethylphenyl)-6-isobutyl quinoline synthesis method. The method comprises S1, preparing 6-isobutyl quinoline as a first intermediate, S2, preparing 2-(3, 5-dimethylphenyl)-6-isobutyl-1, 2-dihydro-quinoline as a second intermediate, S3, dissolving the 2-(3, 5-dimethylphenyl)-6-isobutyl-1, 2-dihydro-quinoline in a solvent, heating the solution to a temperature of 60 DEG C, adding an oxidizing agent into the solution for a reaction at a temperature of 0-100 DEG C, then cooling the product to a temperature of 0 DEG C, carrying out filtration when a lot of solids are separated and carrying out drying to obtain a finished product. The method can realize industrial production of high-purity 2-(3, 5-dimethylphenyl)-6-isobutyl quinoline, has a cost lower than that of the prior art and has a good market promotion prospect. The synthesis method is free of a purification process, reduces an organic waste yield in manufacture, saves resources and protects the environment.
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