Application of loganin in preparation of drugs or health care products for improving sleep
Belonging to the field of compound drugs, the invention relates to pharmaceutical new use of loganin, especially the use of loganin in preparation of drugs or health care products for improving sleep. The loganin provided by the invention is one of the main chemical components of Cornaceae plant cor...
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| creator | He Jun Xu Jiekun Zhang Weiku Qiao Haoyi Ye Xiansheng |
| description | Belonging to the field of compound drugs, the invention relates to pharmaceutical new use of loganin, especially the use of loganin in preparation of drugs or health care products for improving sleep. The loganin provided by the invention is one of the main chemical components of Cornaceae plant cornus officinalis, the chemical formula is C17H26O10, and the molecular weight is 390.38. Animal experiments confirm that loganin can significantly prolong the total sleep time of mice, and has the characteristic of dose dependent increase of sleep amount. Preliminary action mechanism study shows that loganin possibly induces sleep by increasing the level of 5-HT in mouse brain. To sum up, loganin can be prepared into drugs and health care products with sedative and hypnotic effects, the made dosage forms include granules, tablets, capsules, granules, electuaries, oral liquid, dripping pills, pellets or injections.
本发明属于化合物药物领域，涉及马钱苷的药物新用途，尤其是马钱苷在制备改善睡眠的药物或保健品中的用途。本发明提供的马钱苷(Loganin)系山茱萸科植物山茱萸(Cornus officinalis)的主要化学 |
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本发明属于化合物药物领域，涉及马钱苷的药物新用途，尤其是马钱苷在制备改善睡眠的药物或保健品中的用途。本发明提供的马钱苷(Loganin)系山茱萸科植物山茱萸(Cornus officinalis)的主要化学</description><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160831&DB=EPODOC&CC=CN&NR=105902536A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160831&DB=EPODOC&CC=CN&NR=105902536A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>He Jun</creatorcontrib><creatorcontrib>Xu Jiekun</creatorcontrib><creatorcontrib>Zhang Weiku</creatorcontrib><creatorcontrib>Qiao Haoyi</creatorcontrib><creatorcontrib>Ye Xiansheng</creatorcontrib><title>Application of loganin in preparation of drugs or health care products for improving sleep</title><description>Belonging to the field of compound drugs, the invention relates to pharmaceutical new use of loganin, especially the use of loganin in preparation of drugs or health care products for improving sleep. The loganin provided by the invention is one of the main chemical components of Cornaceae plant cornus officinalis, the chemical formula is C17H26O10, and the molecular weight is 390.38. Animal experiments confirm that loganin can significantly prolong the total sleep time of mice, and has the characteristic of dose dependent increase of sleep amount. Preliminary action mechanism study shows that loganin possibly induces sleep by increasing the level of 5-HT in mouse brain. To sum up, loganin can be prepared into drugs and health care products with sedative and hypnotic effects, the made dosage forms include granules, tablets, capsules, granules, electuaries, oral liquid, dripping pills, pellets or injections.
本发明属于化合物药物领域，涉及马钱苷的药物新用途，尤其是马钱苷在制备改善睡眠的药物或保健品中的用途。本发明提供的马钱苷(Loganin)系山茱萸科植物山茱萸(Cornus officinalis)的主要化学</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNirEKwjAURbM4iPoPzw8oVEuFjqVUnJycXMojfUkDMe-RpH6_GcRZuHC4nLNVz17EO43ZcQA24NlicAHKJJJg_Jk5rjYBR1gIfV5AY6TS8LzqnMAU4V7lvl2wkDyR7NXGoE90-HKnjtfxMdwqEp4oCWoKlKfhfqrbrj63zaVv_mk-L447Jw</recordid><startdate>20160831</startdate><enddate>20160831</enddate><creator>He Jun</creator><creator>Xu Jiekun</creator><creator>Zhang Weiku</creator><creator>Qiao Haoyi</creator><creator>Ye Xiansheng</creator><scope>EVB</scope></search><sort><creationdate>20160831</creationdate><title>Application of loganin in preparation of drugs or health care products for improving sleep</title><author>He Jun ; Xu Jiekun ; Zhang Weiku ; Qiao Haoyi ; Ye Xiansheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN105902536A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2016</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>He Jun</creatorcontrib><creatorcontrib>Xu Jiekun</creatorcontrib><creatorcontrib>Zhang Weiku</creatorcontrib><creatorcontrib>Qiao Haoyi</creatorcontrib><creatorcontrib>Ye Xiansheng</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>He Jun</au><au>Xu Jiekun</au><au>Zhang Weiku</au><au>Qiao Haoyi</au><au>Ye Xiansheng</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Application of loganin in preparation of drugs or health care products for improving sleep</title><date>2016-08-31</date><risdate>2016</risdate><abstract>Belonging to the field of compound drugs, the invention relates to pharmaceutical new use of loganin, especially the use of loganin in preparation of drugs or health care products for improving sleep. The loganin provided by the invention is one of the main chemical components of Cornaceae plant cornus officinalis, the chemical formula is C17H26O10, and the molecular weight is 390.38. Animal experiments confirm that loganin can significantly prolong the total sleep time of mice, and has the characteristic of dose dependent increase of sleep amount. Preliminary action mechanism study shows that loganin possibly induces sleep by increasing the level of 5-HT in mouse brain. To sum up, loganin can be prepared into drugs and health care products with sedative and hypnotic effects, the made dosage forms include granules, tablets, capsules, granules, electuaries, oral liquid, dripping pills, pellets or injections.
本发明属于化合物药物领域，涉及马钱苷的药物新用途，尤其是马钱苷在制备改善睡眠的药物或保健品中的用途。本发明提供的马钱苷(Loganin)系山茱萸科植物山茱萸(Cornus officinalis)的主要化学</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Application of loganin in preparation of drugs or health care products for improving sleep |
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