Synthesis method of 3-hydroxyl diazoester intermediate alkyne compound

The invention provides a synthesis method of a 3-hydroxyl diazoester intermediate alkyne compound. The synthesis method comprises the following steps: with a diazoacetate compound and various kinds of substituted propiolaldehyde as raw materials, synthesizing the 3-hydroxyl diazoester intermediate alkyne compound in a mild alkaline environment. The synthesis method provided by the invention has the advantages of simple operation, mild reaction conditions, cheap and available raw materials, wide reaction substrate adaptability, high product selectivity and yield, environmental friendliness and the like and has a good industrial application prospect. 本发明提供了种3-羟基重氮酯基中间炔类化合物的合成方法，该方法以重氮乙酸酯类化合物与各种取代的丙炔醛为原料，在温和的碱性环境中合成3-羟基重氮酯基中间炔生物。该方法具有操作简单、反应条件温和、原料廉价易得、反应底物适应性广、产物的选择性和产率都很高、绿色环保等优点，具有良好的工业应用前景。