Double-targeting chimeric peptide and application thereof in preparation of anti-tumor metastasis drug

The invention discloses a double-targeting chimeric peptide and an application thereof in preparation of an anti-tumor metastasis drug. The chimeric peptide has an amino acid sequence shown in SEQ ID NO.1, acts on CXCR4+ tumor cells in a targeting manner, performs synergistic inhibition of a CXCR4/SDF-1a functional axis and an NF-kB signaling pathway in the tumor cells, and reduces CXCR4+ tumor cell migration and invasion abilities. Specifically, the chimeric peptide is formed by engomphosis of an SDF-1a N-terminal sequence and a nuclear localization sequence (NLS) of an NF-kB P50 subunit; a tumor cell surface receptor CXCR4 is identified through the N-terminal sequence in a targeting manner, and the intracellular SDF-1a/CXCR4 function axis role is inhibited; and the chimeric peptide also as a membrane penetrating peptide promotes the NF-kB P50 subunit NLS sequence to effectively enter the tumor cells, inhibits NF-kB nuclear import transcription process in a targeting manner, and has important value in study