Isoquinoline-1,3(2H,4H)-diketone containing naphthenic nitrile group, and preparation method and use of isoquinoline-1,3(2H,4H)-diketone

The invention discloses an isoquinoline-1,3(2H,4H)-diketone compound containing a naphthenic nitrile group, and a preparation method and use of the isoquinoline-1,3(2H,4H)-diketone compound. The isoquinoline-1,3(2H,4H)-diketone compound has a structure as shown in formula (I); the preparation method takes N-isobutylene acyl-N-alkyl benzamide as a reaction starting material, 1,1'-azobis dicyclohexyl nitrile as a free radical source material, K3PO4 as alkali and dimethyl formamide (DMF) as a solvent, and comprises the steps of carrying out a reaction at the temperature of 85 DEG C in an air environment; after the reaction is carried out for 8 hours, separating and purifying by column chromatography or thin-layer chromatography to obtain the isoquinoline-1,3(2H,4H)-diketone compound. The compounds has a very high inhibition effect for prostate cancer cells (LNCap cells), and particularly, one or two of the compounds are very promising, so that an excellent opportunity is provided for finding out a lead compound