Curcumin micelle drug-loaded system and preparation method thereof

The invention relates to a novel micelle drug-loaded system formed by an amphiphilic segmented copolymer and curcumin. The amphiphilic segmented copolymer comprises a hydrophilic chain segment and a hydrophobic chain segment; the hydrophilic chain segment is polyethylene glycol monomethyl ether, the hydrophobic chain segment is polycaprolactone, and the hydrophobic chain segment is terminated by a hydrophobic group. The hydrophobic group is the group having a tertbutyloxycarbonyl or phenyl ring structure, compatibility of the medicine molecules and the hydrophobic chain segment in the segmented copolymer is improved, mutual effort is increased, at the same time, the hydrophobic group provides large space for accommodating the medicine molecules, the prepared micelle can effectively inhibit the medicine molecules in a core of the micelle, and the medicine molecules are not easy to dissolve out, so that the drug-loaded micelle having high stability can be obtained. 本发明涉及种新型的两亲性嵌段共聚物与姜黄素形成的胶束载药系统。该两亲性嵌段共聚物包括亲水性链