Subsituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heterapahanes and meatllocenes useful for treating HCV infections
The present disclosure provides substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes, of Formula (I) D-M-D (Formula I) useful as antiviral agents. In certain embodiments disclosed herein M is a group -P-A-P- where A is the Formula (I). Certain substitu...
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| creator | PHADKE AVINASH WANG XIANGZHU WANG QUIPING CHEN DAWEI GADHACHANDA VENKAT WILES JASON ALLAN HASHIMOTO AKIHIRO PAIS GODWIN DESHPANDE MILIN |
| description | The present disclosure provides substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes, of Formula (I) D-M-D (Formula I) useful as antiviral agents. In certain embodiments disclosed herein M is a group -P-A-P- where A is the Formula (I). Certain substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. Pharmaceutical compositions/ and combinations containing one or more substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes and a pharmaceutically acceptable carrier are also provided by this disclosure. Methods for treating viral infections, including Hepatitis C viral infections are provided by the disclosure.
本公开内容提供了可用作抗病毒剂的式(I)D?M?D(式I)的经取代的脂肪芬、环芬、异芬、杂芬、杂?异芬以及金属茂。在本文公开的某些实施方案中，M是基团?P?A?P?，其中A是式(I)。本文公开的某些经取代的脂肪芬、环芬、异芬、杂芬、杂?异芬以及金属茂是强效和/或选择性的病毒复制(特别是丙型肝炎病毒 |
| format | Patent |
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本公开内容提供了可用作抗病毒剂的式(I)D?M?D(式I)的经取代的脂肪芬、环芬、异芬、杂芬、杂?异芬以及金属茂。在本文公开的某些实施方案中，M是基团?P?A?P?，其中A是式(I)。本文公开的某些经取代的脂肪芬、环芬、异芬、杂芬、杂?异芬以及金属茂是强效和/或选择性的病毒复制(特别是丙型肝炎病毒</description><language>chi ; eng</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160727&DB=EPODOC&CC=CN&NR=105801467A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160727&DB=EPODOC&CC=CN&NR=105801467A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PHADKE AVINASH</creatorcontrib><creatorcontrib>WANG XIANGZHU</creatorcontrib><creatorcontrib>WANG QUIPING</creatorcontrib><creatorcontrib>CHEN DAWEI</creatorcontrib><creatorcontrib>GADHACHANDA VENKAT</creatorcontrib><creatorcontrib>WILES JASON ALLAN</creatorcontrib><creatorcontrib>HASHIMOTO AKIHIRO</creatorcontrib><creatorcontrib>PAIS GODWIN</creatorcontrib><creatorcontrib>DESHPANDE MILIN</creatorcontrib><title>Subsituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heterapahanes and meatllocenes useful for treating HCV infections</title><description>The present disclosure provides substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes, of Formula (I) D-M-D (Formula I) useful as antiviral agents. In certain embodiments disclosed herein M is a group -P-A-P- where A is the Formula (I). Certain substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. Pharmaceutical compositions/ and combinations containing one or more substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes and a pharmaceutically acceptable carrier are also provided by this disclosure. Methods for treating viral infections, including Hepatitis C viral infections are provided by the disclosure.
本公开内容提供了可用作抗病毒剂的式(I)D?M?D(式I)的经取代的脂肪芬、环芬、异芬、杂芬、杂?异芬以及金属茂。在本文公开的某些实施方案中，M是基团?P?A?P?，其中A是式(I)。本文公开的某些经取代的脂肪芬、环芬、异芬、杂芬、杂?异芬以及金属茂是强效和/或选择性的病毒复制(特别是丙型肝炎病毒</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZGgPLk0qziwpLUlNUUjMySzISMxLLdZRSK5MzsmHcTJSS1KLElF4qHL5ulAliWBRhcS8FIXc1MSSnJz85FSQQGlxalppjkJafpFCSRFQIjMvXcHDOUwhMy8tNbkkMz-vmIeBNS0xpziVF0pzMyi6uYY4e-imFuTHpxYXJIIMKol39jM0MLUwMDQxM3c0JkYNAAVYTJ4</recordid><startdate>20160727</startdate><enddate>20160727</enddate><creator>PHADKE AVINASH</creator><creator>WANG XIANGZHU</creator><creator>WANG QUIPING</creator><creator>CHEN DAWEI</creator><creator>GADHACHANDA VENKAT</creator><creator>WILES JASON ALLAN</creator><creator>HASHIMOTO AKIHIRO</creator><creator>PAIS GODWIN</creator><creator>DESHPANDE MILIN</creator><scope>EVB</scope></search><sort><creationdate>20160727</creationdate><title>Subsituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heterapahanes and meatllocenes useful for treating HCV infections</title><author>PHADKE AVINASH ; WANG XIANGZHU ; WANG QUIPING ; CHEN DAWEI ; GADHACHANDA VENKAT ; WILES JASON ALLAN ; HASHIMOTO AKIHIRO ; PAIS GODWIN ; DESHPANDE MILIN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN105801467A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2016</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>PHADKE AVINASH</creatorcontrib><creatorcontrib>WANG XIANGZHU</creatorcontrib><creatorcontrib>WANG QUIPING</creatorcontrib><creatorcontrib>CHEN DAWEI</creatorcontrib><creatorcontrib>GADHACHANDA VENKAT</creatorcontrib><creatorcontrib>WILES JASON ALLAN</creatorcontrib><creatorcontrib>HASHIMOTO AKIHIRO</creatorcontrib><creatorcontrib>PAIS GODWIN</creatorcontrib><creatorcontrib>DESHPANDE MILIN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PHADKE AVINASH</au><au>WANG XIANGZHU</au><au>WANG QUIPING</au><au>CHEN DAWEI</au><au>GADHACHANDA VENKAT</au><au>WILES JASON ALLAN</au><au>HASHIMOTO AKIHIRO</au><au>PAIS GODWIN</au><au>DESHPANDE MILIN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Subsituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heterapahanes and meatllocenes useful for treating HCV infections</title><date>2016-07-27</date><risdate>2016</risdate><abstract>The present disclosure provides substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes, of Formula (I) D-M-D (Formula I) useful as antiviral agents. In certain embodiments disclosed herein M is a group -P-A-P- where A is the Formula (I). Certain substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. Pharmaceutical compositions/ and combinations containing one or more substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes and a pharmaceutically acceptable carrier are also provided by this disclosure. Methods for treating viral infections, including Hepatitis C viral infections are provided by the disclosure.
本公开内容提供了可用作抗病毒剂的式(I)D?M?D(式I)的经取代的脂肪芬、环芬、异芬、杂芬、杂?异芬以及金属茂。在本文公开的某些实施方案中，M是基团?P?A?P?，其中A是式(I)。本文公开的某些经取代的脂肪芬、环芬、异芬、杂芬、杂?异芬以及金属茂是强效和/或选择性的病毒复制(特别是丙型肝炎病毒</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | Subsituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heterapahanes and meatllocenes useful for treating HCV infections |
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