(R)-Lansoprazole time-selection pulse controlled-release pellet preparation and preparation method thereof
The invention discloses an (R)-Lansoprazole time-selection pulse controlled-release pellet preparation and a preparation method thereof.The basic structure of the preparation comprises a blank pellet core, a medicine layer, a swelling layer and an enteric controlled release layer from inside to outs...
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| creator | DAI LINNAN HAN XIAOPENG YIN LIFANG TANG XIAOJIE |
| description | The invention discloses an (R)-Lansoprazole time-selection pulse controlled-release pellet preparation and a preparation method thereof.The basic structure of the preparation comprises a blank pellet core, a medicine layer, a swelling layer and an enteric controlled release layer from inside to outside.The swelling layer contains swelling materials and a binding agent, and the enteric controlled release layer contains enteric materials and sustained-release materials.Compared with routine technologies, the release rate of the pellets, prepared through the preparation method, in a 0.1 mol/L hydrochloric acid solution is smaller than 10% of labeled amount within two hours of tolerance, certain time lag is presented at the upper end of the small intestine, and then quick pulse controlled-release is conducted.Adopted adjuvant is easy to get, the production technology is simple and controllable, and the preparation is suitable for industrial production.
本发明公开了种右旋兰索拉唑择时脉冲控释微丸制剂及其制备方法，基本结构由内至外包括空白丸芯、药物层、溶胀层和肠溶控释层。其中 |
| format | Patent |
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本发明公开了种右旋兰索拉唑择时脉冲控释微丸制剂及其制备方法，基本结构由内至外包括空白丸芯、药物层、溶胀层和肠溶控释层。其中</description><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160727&DB=EPODOC&CC=CN&NR=105796531A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160727&DB=EPODOC&CC=CN&NR=105796531A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DAI LINNAN</creatorcontrib><creatorcontrib>HAN XIAOPENG</creatorcontrib><creatorcontrib>YIN LIFANG</creatorcontrib><creatorcontrib>TANG XIAOJIE</creatorcontrib><title>(R)-Lansoprazole time-selection pulse controlled-release pellet preparation and preparation method thereof</title><description>The invention discloses an (R)-Lansoprazole time-selection pulse controlled-release pellet preparation and a preparation method thereof.The basic structure of the preparation comprises a blank pellet core, a medicine layer, a swelling layer and an enteric controlled release layer from inside to outside.The swelling layer contains swelling materials and a binding agent, and the enteric controlled release layer contains enteric materials and sustained-release materials.Compared with routine technologies, the release rate of the pellets, prepared through the preparation method, in a 0.1 mol/L hydrochloric acid solution is smaller than 10% of labeled amount within two hours of tolerance, certain time lag is presented at the upper end of the small intestine, and then quick pulse controlled-release is conducted.Adopted adjuvant is easy to get, the production technology is simple and controllable, and the preparation is suitable for industrial production.
本发明公开了种右旋兰索拉唑择时脉冲控释微丸制剂及其制备方法，基本结构由内至外包括空白丸芯、药物层、溶胀层和肠溶控释层。其中</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjLEKwkAQRNNYiPoPZ6fFgSFEsZSgWIiF2IclmZDI5Xa5Wxu_3kNs7KyGN_OYafZY3db2Qj6yBHqxg9FhhI1waHRgb-TpIkzDXgM7h9aGNFGqBAnVSIBQoI9Lvv3hEdpza7RHAHfzbNJROlt8c5YtT8d7dbYQrhGFGnhoXV3zTbnbb8siPxT_OG_U80HF</recordid><startdate>20160727</startdate><enddate>20160727</enddate><creator>DAI LINNAN</creator><creator>HAN XIAOPENG</creator><creator>YIN LIFANG</creator><creator>TANG XIAOJIE</creator><scope>EVB</scope></search><sort><creationdate>20160727</creationdate><title>(R)-Lansoprazole time-selection pulse controlled-release pellet preparation and preparation method thereof</title><author>DAI LINNAN ; HAN XIAOPENG ; YIN LIFANG ; TANG XIAOJIE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN105796531A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2016</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>DAI LINNAN</creatorcontrib><creatorcontrib>HAN XIAOPENG</creatorcontrib><creatorcontrib>YIN LIFANG</creatorcontrib><creatorcontrib>TANG XIAOJIE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DAI LINNAN</au><au>HAN XIAOPENG</au><au>YIN LIFANG</au><au>TANG XIAOJIE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>(R)-Lansoprazole time-selection pulse controlled-release pellet preparation and preparation method thereof</title><date>2016-07-27</date><risdate>2016</risdate><abstract>The invention discloses an (R)-Lansoprazole time-selection pulse controlled-release pellet preparation and a preparation method thereof.The basic structure of the preparation comprises a blank pellet core, a medicine layer, a swelling layer and an enteric controlled release layer from inside to outside.The swelling layer contains swelling materials and a binding agent, and the enteric controlled release layer contains enteric materials and sustained-release materials.Compared with routine technologies, the release rate of the pellets, prepared through the preparation method, in a 0.1 mol/L hydrochloric acid solution is smaller than 10% of labeled amount within two hours of tolerance, certain time lag is presented at the upper end of the small intestine, and then quick pulse controlled-release is conducted.Adopted adjuvant is easy to get, the production technology is simple and controllable, and the preparation is suitable for industrial production.
本发明公开了种右旋兰索拉唑择时脉冲控释微丸制剂及其制备方法，基本结构由内至外包括空白丸芯、药物层、溶胀层和肠溶控释层。其中</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | (R)-Lansoprazole time-selection pulse controlled-release pellet preparation and preparation method thereof |
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