(R)-Lansoprazole time-selection pulse controlled-release pellet preparation and preparation method thereof
The invention discloses an (R)-Lansoprazole time-selection pulse controlled-release pellet preparation and a preparation method thereof.The basic structure of the preparation comprises a blank pellet core, a medicine layer, a swelling layer and an enteric controlled release layer from inside to outs...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses an (R)-Lansoprazole time-selection pulse controlled-release pellet preparation and a preparation method thereof.The basic structure of the preparation comprises a blank pellet core, a medicine layer, a swelling layer and an enteric controlled release layer from inside to outside.The swelling layer contains swelling materials and a binding agent, and the enteric controlled release layer contains enteric materials and sustained-release materials.Compared with routine technologies, the release rate of the pellets, prepared through the preparation method, in a 0.1 mol/L hydrochloric acid solution is smaller than 10% of labeled amount within two hours of tolerance, certain time lag is presented at the upper end of the small intestine, and then quick pulse controlled-release is conducted.Adopted adjuvant is easy to get, the production technology is simple and controllable, and the preparation is suitable for industrial production.
本发明公开了种右旋兰索拉唑择时脉冲控释微丸制剂及其制备方法,基本结构由内至外包括空白丸芯、药物层、溶胀层和肠溶控释层。其中 |
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