Molecular targets for the prevention and/or treatment of fibrosis, hypertrophic scars or keloids

The present invention relates to a therapeutic compound comprising: an agent that inhibits the activity of at least one gene selected from the group consisting of HICl, FOXSl, CREB5, IRF7, POU2F2, STAT4, TCF4, and/or an agent that enhances the activity of at least one gene selected from the group co...

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Bibliographische Detailangaben
Hauptverfasser:	DARZACQ XAVIER, DUGAST-DARZACQ CLAIRE, NOIZET MAITE
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a therapeutic compound comprising: an agent that inhibits the activity of at least one gene selected from the group consisting of HICl, FOXSl, CREB5, IRF7, POU2F2, STAT4, TCF4, and/or an agent that enhances the activity of at least one gene selected from the group consisting of MAF, MEOX2, SIX2. 本发明涉及用于预防和/或治疗纤维化、增生性疤痕或疤痕疙瘩的治疗性化合物，包含：-抑制至少个选自HIC1、FOXS1、CREB5、IRF7、POU2F2、STAT4、TCF4,优选TCF4、FOXS1、STAT4的基因的活性的试剂，和/或-增强至少个选自MAF、MEOX2、SIX2的基因的活性的试剂。