Preparation method of N-coumaroyldopamine

The invention discloses a preparation method of N-coumaroyldopamine. The preparation method includes adding 3-hydroxytyramine hydrobromide, methyl p-hydroxycinnamate, and alkaline into a four-port round-bottom flask as well as solvent, stirring, and finishing thin-layer chromatography detection reaction; adding water into reaction solution to separate, adding ethyl acetate for extraction, washing organic phase with saturated salt solution, washing inorganic phase with diluted hydrochloric acid, drying with anhydrous sodium sulfate, filtering, and concentrating to obtain pulp; adding petroleum ether into the pulp, heating to reflow, cooling and standing, pouring solution on the upper layer, adding ethyl acetate into the pulp, mixing, filtering and drying to obtain white solids. Through authentication of nuclear magnetism, the product is N-coumaroyldopamine. In the preparation method of N-coumaroyldopamine, the final product is synthesized directly at one step, synthesis steps are greatly reduced, and productio