Preparation method of 3-cyano-5-methoxy-2-methylindole

The invention provides a preparation method of 3-cyano-5-methoxy-2-methylindole, comprising the following steps: mixing 5-methoxy-2-methylindole, K4[F3(CN)6].3H2O, a catalyst, a catalyst promoter and an organic solvent to obtain a reaction system, the catalyst being glycine palladium chloride complex, and providing green atom-economic cyanation reaction by catalytic C-H activation to obtain the 3-cyano-5-methoxy-2-methylindole.Compared with the prior art, the preparation method of the invention uses the glycine palladium chloride complex as the catalyst replacing traditional Pd(OAc)2, and the yield of 3-cyano-5-methoxy-2-methyindole can be greatly increased.Results of an embodiment of the invention show that the yield of the 3-cyano-5-methoxy-2-methylindole by the method provided herein is higher than 78%, up to 83.90%. 本发明提供了种3?氰基?5甲氧基?2?甲基吲哚的制备方法，包括以下步骤：将5?甲氧基?2?甲基吲哚、K[Fe(CN)]·3HO、催化剂、助催化剂和有机溶剂进行混合，得到反应体系，所述催化剂为氨基乙酸氯化钯配合物，催化C?H活化提供了绿色、原子经济的氰基化反应，得到3?氰基?5甲氧基?2?甲基吲哚。与现有技术相比，本发明提供的制备方法选用氨基乙酸氯化钯配合物代替传统的Pd(OAc)作