Cancer biomarkers and uses thereof

The invention relates the use of Human Epidermal Growth Factor Receptor 2 (HER2) gene copy number and HER2 mRNA levels as biomarkers to identify cancers which will respond to treatment with a specific binding member comprising a HER2 antigen binding site engineered into a structural loop region of a...

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Bibliographische Detailangaben
Hauptverfasser:	ROWLAND ROBERT, BATEY SARAH, LIANG JIANMEI, SUN HAIJUN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates the use of Human Epidermal Growth Factor Receptor 2 (HER2) gene copy number and HER2 mRNA levels as biomarkers to identify cancers which will respond to treatment with a specific binding member comprising a HER2 antigen binding site engineered into a structural loop region of a constant domain, e.g. CH3 domain, of the specific binding member, and specific binding members which compete with such a binding member for binding to HER2. 本发明涉及人表皮生长因子受体2(HER2)基因拷贝数和HER2mRNA水平作为生物标记物用于鉴别癌症的用途，所述癌症对采用特异性结合成分的治疗有反应，所述特异性结合成分含有工程化于特异性结合成分恒定区(如CH3结构域)结构性环区的HER2抗原结合位点，且所述特异性结合成分与该结合成分竞争性结合于HER。