Composition of a non-nucleoside reverse transcriptase inhibitor

The invention encompasses a composition comprising the reverse transcriptase (RT) inhibitor 3-chloro-5-({1-[(4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl}oxy)benzonitrile sufficiently mixed in a concentration enhancing polymer, and proces...

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Bibliographische Detailangaben
Hauptverfasser:	PLOEGER KRISTIN J M, LOWINGER MICHAEL, TATAVARTI ADITYA S, MARSAC PATRICK JULES, BLOOM COREY J, BROOKHART KATHERINE ANNE
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES FISHING FORESTRY HUMAN NECESSITIES HUNTING PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF TRAPPING
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Beschreibung
Zusammenfassung:	The invention encompasses a composition comprising the reverse transcriptase (RT) inhibitor 3-chloro-5-({1-[(4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl}oxy)benzonitrile sufficiently mixed in a concentration enhancing polymer, and processes for making the same. The composition and processes of the present invention significantly improve the bioavailability of the aforementioned RT inhibitor, while maintaining physical stability. 本发明包括包含在提高浓度的聚合物中充分混合的逆转录酶("RT")抑制剂3?氯?5?({1?[(4?甲基?5?氧代?4,5?二氢?1H?1,2,4?三唑?3?基)甲基]?2?氧代?4?(三氟甲基)?1,2?二氢吡啶?3?基}氧基)苄腈的组合物和制备它们的方法。本发明的组合物和方法会显著地提高前述RT抑制剂的生物利用度，同时维持物理稳定性。