Preparation method for high-quality irinotecan hydrochloride trihydrate crystal forms

The invention provides a preparation method for high-quality irinotecan hydrochloride trihydrate crystal forms, relates to the technical field of medicine preparation, and particularly discloses high-quality irinotecan hydrochloride and a purification method of the high-quality irinotecan hydrochlor...

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Hauptverfasser: ZHANG DUQIAN, ZHOU YUBAO, BIAN HONGLING, HUANG YE, ZHU JIANRONG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides a preparation method for high-quality irinotecan hydrochloride trihydrate crystal forms, relates to the technical field of medicine preparation, and particularly discloses high-quality irinotecan hydrochloride and a purification method of the high-quality irinotecan hydrochloride. According to the method, by replacing traditional column chromatography with Buchner funnel suction filtration, the problems that in the prior art, when purification is conducted through column chromatography, the use amount of solvent is large, the production period is long, the number of impurities wrapped in the crystal forms is large, purity and yield are low, environment pollution is caused, cost is high and industrialized mass production can not be easily conducted are solved. According to the method, large-scale production operation is simple, the use amount of solvent is small, the production period is short, and yield and purity are both remarkably improved. The normalization purity of irinotecan puri