Bufalin-loaded polypeptide-modified poly(oligo(ethylene glycol)methacrylate)-polycaprolactone (Ph PCL b P(OEGMA co RGD) bufalin) nanometer preparation

The invention belongs to the technical field of a tumor targeting deliverying and slow release administration system. The invention relates to a bufalin-loaded valine-arginine-glycine-aspartic acid-glutamic acid cyclopeptide (cRGD)-modified poly(oligo(ethylene glycol)methacrylate)-polycaprolactone (Ph PCL b P(OEGMA co RGD) bufalin) nanometer particle and a preparation method thereof. Ph-PCL-b-P(OEGMA-co-GMA) as a base material is modified through cRGD to form Ph-PCL-b-P(OEGMA-co-RGD) and bufalin is wrapped by micelle of the Ph-PCL-b-P(OEGMA-co-RGD) so that (Ph PCL b P(OEGMA co RGD) bufalin) nanometer particles are prepared. The nanometer preparation can effectively reduce toxic or side effect of bufalin and improve water solubility and tumor targeting ability. The bufalin is slowly released along with material degradation so that long-term treatment effects are obtained. 本发明属于肿瘤靶向递送与缓释给药系统技术领域。涉及一种附载蟾毒灵的缬氨酸-精氨酸-甘氨酸-天冬氨酸-谷氨酸环肽(cRGD)修饰的聚甲基丙烯酸寡聚乙二醇酯-聚己内酯纳米粒及其制备方法。本发明中以Ph-PCL-b-P(OEGMA-co- GMA)为基础材料经cRGD修饰成Ph-PCL