Long-acting diclofenac transdermal patch and preparation technology thereof

The invention discloses a long-acting diclofenac transdermal patch and a preparation technology thereof and belongs to the technical field of medicine. The preparation is mainly prepared from a diclofenac bulk pharmaceutical chemical, a penetration enhancer, a dispersing solvent and a polyacrylate pressure-sensitive adhesive. The long-acting diclofenac transdermal patch and the preparation technology thereof have the following advantages: (1) the drug can be released from a matrix continuously for 12-48 h, the drug remaining amount is low, the percutaneous absorption is excellent, and the drug delivery times and dosage can be reduced; (2) a product has no skin irritation and has good adhesion and flexibility; (3) the main drug and the additives are stable in a viscose matrix; (4) the preparation technology is simple, convenient and pollution-free. 本发明公开了一种长效双氯芬酸类透皮贴剂及其制备工艺，属于医药技术领域。制剂主要由双氯芬酸类原料药、促渗剂、分散溶剂、聚丙烯酸酯压敏胶组成。本发明具有以下优点：(1)药物可以12～48h持续从基质中释放，残药量低，经皮吸收性优异，可以减少给药次数及给药量；(2)产品无皮肤刺激性，且粘附性，柔顺性好；(3)主药及添加剂在黏胶基质中