Novel methods and antibodies for treating coagulapathy

The present invention relates to pro-coagulant human Protein S inhibitors, such as antibodies or antigen-binding fragments thereof that can be administered subcutaneously as prophylactic treatment for haemophilia patients regardless of inhibitor status and without interfering with non-coagulant func...

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Bibliographische Detailangaben
Hauptverfasser:	HEIBROCH HELLE, WATERS EMILY, ANDERSEN LISBETH MOREAU, KROGH BERIT OLSEN, ANDERSEN METTE DAHL, HERMIT METTE BRUNSGAARD, KJAERGAARD KRISTIAN, SALBO RUNE, BALLING KRISTOFFER WINTHER, HOLMBERG HEIDI LINDGREEN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to pro-coagulant human Protein S inhibitors, such as antibodies or antigen-binding fragments thereof that can be administered subcutaneously as prophylactic treatment for haemophilia patients regardless of inhibitor status and without interfering with non-coagulant functions of Protein S. 本发明涉及促凝血的人蛋白S抑制剂，例如可皮下施用作为血友病患者的预防性治疗的抗体或其抗原结合片段，其作用与抑制物状态无关且不干扰蛋白S的非凝血功能。