Preparation method of alpha-acyloxyketone compound

The invention discloses a preparation method of an alpha-acyloxyketone compound. The preparation method comprises 1, mixing an aromatic ketone shown in the formula (II), a copper salt and an organic solvent and preheating the mixture to obtain a mixed system, 2, mixing a carboxylic acid shown in the...

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Hauptverfasser: XIE QIGUANG, YAN LIQIN, PANG SHUFEN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a preparation method of an alpha-acyloxyketone compound. The preparation method comprises 1, mixing an aromatic ketone shown in the formula (II), a copper salt and an organic solvent and preheating the mixture to obtain a mixed system, 2, mixing a carboxylic acid shown in the formula (III) and an alkali compound, adding the mixture into the mixed system and carrying out a contact reaction process to obtain the alpha-acyloxyketone compound shown in the formula (I), wherein in the formula (I), R1, R2, R3, R4, R5, R6 and R7 respectively represent H, halogen, alkyl, substituted alkyl, aryl, substituted aryl, a heterocyclic substituent group, alkenyl, alkylacyloxy, phenylacyloxy, alkyloxy, aryloxy, an alkylamino group, an arylamino group or a nitro group. The preparation method is convenient for operation, has excellent yield and efficiency, utilizes easily available raw materials and can be widely used. 本发明公开了一种α-酰氧基酮类化合物的制备方法,包括:1)将如式(II)所示结构的芳香酮、铜盐与有机溶剂混合并预热形成混合体系;2)将如式(III)所示结构的羧酸、碱性化合物