Polypeptide modified poly(oligo(ethylene glycol) methacrylate-co-bufalin) nano preparation, and preparation method thereof

The invention belongs to the technical field of tumor targeted delivery and sustained release drug delivery system, and relates to a polypeptide modified poly(oligo(ethylene glycol) methacrylate-co-bufalin) nano preparation, and a preparation method thereof. According to the preparation method, P(OEGMA-co-BSMA) is taken as a base material, esterification and ammonolysis reaction are adopted so as to realize covalent modification of cRGD and bufalin onto the polymer so as to obtain the polypeptide modified poly(oligo(ethylene glycol) methacrylate-co-bufalin) nano preparation (P(OEGMA-co-RGD-co-bufalin) for short). The prepared tumor targeted nano drug is capable of reducing toxic and side effect of bufalin, and improving water solubility and tumor target ability; the long chain of POEGMA is capable of realizing escape of a nano carrier from cytophagy of the reticuloendothelial system, so that long circulation is realized, and excellent curative effect is achieved; and at the same time, targeting effect of the