Non-coding small RNA molecule ncRNA1351 of Brucella and application of non-coding small RNA molecule ncRNA1351

The invention discloses a non-coding small RNA molecule (small non-coding RNA, sRNA) derived from Brucella. The non-coding small RNA molecule is named ncRNA1351. The nucleotide sequence of the non-coding small RNA molecule is shown in SEQ ID NO:1 in a sequence table. It is proved through a Northern...

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Bibliographische Detailangaben
Hauptverfasser:	YANG XIAOLI, ZHANG XIAOLI, WENG ZEBING, WANG LI, LIU JIA, SONG LIJIE, SUN TAO, ZHANG WEI, WANG XIUMEI, WANG YUFEI, HAO QINFANG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses a non-coding small RNA molecule (small non-coding RNA, sRNA) derived from Brucella. The non-coding small RNA molecule is named ncRNA1351. The nucleotide sequence of the non-coding small RNA molecule is shown in SEQ ID NO:1 in a sequence table. It is proved through a Northern blot experiment that ncRNA1351 exists in Brucella. Functions of ncRNA1351 are analyzed by people by constructing a Brucella deletion mutation strain and reply strain of Brucella. It is proved trough an experimental result that after ncRNA1351 is deleted, the survivability of Brucella under the pressure condition of a simulated macrophage internal environment is obviously weakened, the survivability of Brucella in a mouse is reduced, and it is indicated that ncRNA1351 is relevant to the toxicity of Brucella. Thus, anti-Brucella drugs can be prepared with ncRNA1351 as a target. The non-coding small RNA molecule plays an important role in prevention and treatment of brucellosis, and application prospects are wide.