N-tert-butyloxycarbonyl-7-(aminomethyl)-6-oxo-2-spiro[4.5]decane synthesis method

The present invention relates to a N-tert-butyloxycarbonyl-7-(aminomethyl)-6-oxo-2-spiro[4.5]decane synthesis method. In the prior art, the current technology lacks of the industrial synthesis method of N-tert-butyloxycarbonyl-7-(aminomethyl)-6-oxo-2-spiro[4.5]decane. The synthesis steps comprise th...

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Bibliographische Detailangaben
Hauptverfasser:	NIU YANXIA, YU LINGBO, FENG JIANLONG, GAO MINGFEI, MAO YANJUN, MA RUJIAN, ZHOU QIANG, ZHANG YONGLI, HE ZHENMIN, WANG RUILE, XU XUEQIN, BAI XUE, CHEN DONGZHI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The present invention relates to a N-tert-butyloxycarbonyl-7-(aminomethyl)-6-oxo-2-spiro[4.5]decane synthesis method. In the prior art, the current technology lacks of the industrial synthesis method of N-tert-butyloxycarbonyl-7-(aminomethyl)-6-oxo-2-spiro[4.5]decane. The synthesis steps comprise that a conventional industrial raw material N-tert-butyloxycarbonyl-3-pyrrolidone is adopted as a starting raw material and reacts with a pentene Grignard reagent to obtain N-tert-butyloxycarbonyl-3-hydroxy-3-pentene pyrrole, the N-tert-butyloxycarbonyl-3-hydroxy-3-pentene pyrrole and m-chloroperbenzoic acid are subjected to ring closure to obtain N-tert-butyloxycarbonyl-7-(hydroxymethyl)-6-oxo-2-spiro[4.5]decane, the N-tert-butyloxycarbonyl-7-(hydroxymethyl)-6-oxo-2-spiro[4.5]decane, dichloromethane and methanesulfonyl chloride are stirred at a room temperature under an alkaline condition to obtain N-tert-butyloxycarbonyl-7-(methyl sulfonyl oxy methyl)-6-oxo-2-spiro[4.5]decane, and the N-tert-butyloxycarbonyl-7-(met