Composition and application thereof, and stabilizer containing composition

The invention relates to the technical field of biology, particularly a composition and application thereof, and a stabilizer containing the composition. The composition comprises one or mixture of more of chlorides, amino acids, saccharides or surfactants. By using the composition, the purity of the effective components (containing dimers and monomers) of recombinant human calcineurin B subunit (rhCNB for short) is up to 99% or above, wherein the dimer purity is stably controlled at 98% or above, and the impurity polymer content is less than 0.5%. Thus, the indexes of the composition achieve the international advanced level of biological medicines, thereby effectively solving the problem of low stability in the rhCNB production and storage process. When the composition stabilizer provided by the invention is added, after the rhCNB is stored at 37 DEG C for 6 months, the composition ratio and bioactivity of the rhCNB do not obviously change, and various quality indexes do not obviously change.