Bonded chiral amino alcohol polymer and preparation method and application thereof

The invention discloses a bonded chiral amino alcohol polymer and a preparation method and application thereof. The bonded chiral amino alcohol polymer is composed of chiral amino acid derivative monomers on modified silica gel by virtue of amide group bonding. The preparation method comprises the f...

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Bibliographische Detailangaben
Hauptverfasser: LIU FENGLIANG, NIE ZUOBING, LI CUIQIN, FENG SI, LIU RUILI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a bonded chiral amino alcohol polymer and a preparation method and application thereof. The bonded chiral amino alcohol polymer is composed of chiral amino acid derivative monomers on modified silica gel by virtue of amide group bonding. The preparation method comprises the following steps: taking L-amino acid as a raw material, and sequentially performing methyl esterification and phenylmagnesium bromide addition; introducing double bonds through acryloyl chloride, thereby obtaining a chiral monomer; polymerizing the chiral monomer and modified silica gel introduced with double bonds through free radicals, thereby obtaining the product. The process is simple in method, wide in raw material source and low in cost and is beneficial to industrial production; and moreover, the bonded chiral amino alcohol polymer has organic solvent resistance and high chiral resolution performance, can serve as a novel HPLC chiral stationary phase material applied to chiral compound identification or reso