N-cyclopropane substituent-containing curcumin analogue and drug application thereof

The invention discloses an N-cyclopropane substituent-containing curcumin analogue. The molecular expression of the curcumin analogue is (3E,5E)-3-(3-allyl-4-hydroxyl benzylidene)-1-cyclopropyl-5-(2,4-dimethoxy benzylidene)piperidine-4-ketone. The invention further discloses drug application of the N-cyclopropane substituent-containing curcumin analogue. The N-cyclopropane substituent-containing curcumin analogue is applied to prevention or treatment of sepses induced by bacteria and inflammatory reactions induced by chemical substances, wherein the sepses induced by the bacteria comprise inflammatory factor release induced by lipopolysaccharide (LPS) and septic death induced by the LPS, and the inflammatory reactions induced by the chemical substances comprise ear swelling induced by xylene, vascular permeability increasing caused by intraperitoneal injection of acetic acid and twisting number increasing caused by acetic acid.