Method for preparing Tadalafil solid dispersion and medicinal preparation of Tadalafil solid dispersion
The invention discloses a method for preparing Tadalafil solid dispersion. The method includes the steps that Tadalafil and carriers acceptable in the pharmacy are mixed to be even, heated to be melted, and then cooled, and the Tadalafil solid dispersion is obtained through smashing. The carriers ac...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses a method for preparing Tadalafil solid dispersion. The method includes the steps that Tadalafil and carriers acceptable in the pharmacy are mixed to be even, heated to be melted, and then cooled, and the Tadalafil solid dispersion is obtained through smashing. The carriers acceptable in the pharmacy are selected from povidone, co-povidone and polyethylene caprolactam-polyvinyl acetate-polyethylene glycol grafted copolymers. The invention further discloses Tadalafil tablets containing the solid dispersion. According to the preparing method, no organic solvent needs to be used, safety risks and environment protection pressure can be reduced, production cost is reduced, and commercialized production of products is facilitated. |
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