Method for synthetizing Tebipenem intermediate
The invention discloses a method for synthetizing a Tebipenem intermediate, and belongs to the field of chemical pharmacy. 2- methylthio-4, 5- thiazoline is synthetized by using ethanolamine as a raw material, a disulfide bond and a C-N coupling and breaking disulfide bond are formed through additio...
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| Format: | Patent |
| Sprache: | chi ; eng |
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| Zusammenfassung: | The invention discloses a method for synthetizing a Tebipenem intermediate, and belongs to the field of chemical pharmacy. 2- methylthio-4, 5- thiazoline is synthetized by using ethanolamine as a raw material, a disulfide bond and a C-N coupling and breaking disulfide bond are formed through addition, cyclization, open loop and hydrolysis by using allyl amine as a raw material, and finally the Tebipenem intermediate namely 1- ( 4,5- thiazoline -2- base) azetidine -3- mercaptide hydrochloride is synthetized. The method disclosed by the invention is simple and easy to operate, high in yield, low in pollution and suitable for industrial production. |
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