Fingerprint spectrum determination method for Simotang oral solution

The invention discloses a fingerprint spectrum determination method for a Simotang oral solution. The method comprises the steps that a solution to be tested is prepared; the chromatographic conditions are set in the mode that elastic quartz capillary columns are adopted as chromatographic columns, the program temperature is set in the mode that the initial temperature is set at 45 DEG C-60 DEG C (kept for 7 min), the temperature is increased to 65 DEG C-75 DEG C (kept for 10 min) at the speed of 2 DEG C-3 DEG C/min and then increased to 190 DEG C-210 DEG C at the speed of 2 DEG C-3 DEG C/min, the temperature of a vaporizing chamber is set at 245 DEG C-260 DEG C, an electrospray ion source (EI) is adopted as an ion source, and the mass range is set within 35-400 m/z; the structure of a component corresponding each peak is searched and identified according to a spectrum library, and calculation is performed on the chromatographic peaks through an area normalization method to get the percentages of all the components; determination is performed, wherein determination is performed by adopting a gas chromatography-mass spectrometry instrument, and a 70-min chromatogram map is recorded. The determination method has the advantages that qualitative and quantitative analysis is performed by combining a fingerprint spectrum technique with the gas chromatography-mass spectrometry instrument. The determination method is easy and convenient to operate, good in repeatability and stability and high in specificity. An obtained fingerprint spectrum is better in separation effect of all characteristic peaks and can serve as a standard fingerprint spectrum for determining the ingredients of the Simotang oral solution to identify the effective ingredients of the Simotang oral solution.