Animal model of Charcot-Marie-Tooth disease as HSP27 mutant (S135F) carrier

The present invention relates to an animal model of Charcot-Marie-Tooth disease (CMT) as a HSP27 mutant (S135F) carrier, specifically, an animal model of Charcot-Marie-Tooth disease (CMT) which is used for evaluation of the efficacy of a candidate material for a CMT therapeutic agent by injecting, i...

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Bibliographische Detailangaben
Hauptverfasser:	CHOI BYUNG-OK, KIM YUN-TAE, HONG YOUNG-BIN, JUNG SUNGUL, WOO SO-YOUN, PARK JIN-MO
Format:	Patent
Sprache:	eng
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPIRITS TESTING TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to an animal model of Charcot-Marie-Tooth disease (CMT) as a HSP27 mutant (S135F) carrier, specifically, an animal model of Charcot-Marie-Tooth disease (CMT) which is used for evaluation of the efficacy of a candidate material for a CMT therapeutic agent by injecting, into an embryo of a mouse, a vector expressing a mutant type in which the 135th serine of a HSP27 protein is substituted with phenylalanine, and selecting a mouse having the expression vector so as to check if the mouse exhibits the phenotype of CMT.