Preparation method for oxymatrine microcapsules
The invention discloses a preparation method for oxymatrine microcapsules. The method comprises the following steps that silicon dioxide template materials are prepared, and self-assembling is performed layer upon layer by taking poly allyamine hydrochloride and polystyrene sodium sulfonate as posit...
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| creator | MA YUN SHANG JINGCHUAN WANG JINGWEN LI JING WANG LAN |
| description | The invention discloses a preparation method for oxymatrine microcapsules. The method comprises the following steps that silicon dioxide template materials are prepared, and self-assembling is performed layer upon layer by taking poly allyamine hydrochloride and polystyrene sodium sulfonate as positive and negative polyelectrolytes to prepared template microcapsules which are not denucleated; the template microcapsules which are not denucleated are taken, hydrogen fluoride is added to enable SiO2 to be fully dissolved, and centrifugal cleaning is repeatedly performed with a NaCl solution until the pH is 7. According to the preparation method for the oxymatrine microcapsules, the prepared hollow microcapsules are uniform in size and form, the size of the microcapsules can be actively controlled through the lay number of the polyelectrolytes containing opposite charges, and the form of the microcapsules can be controlled through template nucleuses; accordingly, the drug releasing controllability and targeting property can be improved. |
| format | Patent |
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The method comprises the following steps that silicon dioxide template materials are prepared, and self-assembling is performed layer upon layer by taking poly allyamine hydrochloride and polystyrene sodium sulfonate as positive and negative polyelectrolytes to prepared template microcapsules which are not denucleated; the template microcapsules which are not denucleated are taken, hydrogen fluoride is added to enable SiO2 to be fully dissolved, and centrifugal cleaning is repeatedly performed with a NaCl solution until the pH is 7. According to the preparation method for the oxymatrine microcapsules, the prepared hollow microcapsules are uniform in size and form, the size of the microcapsules can be actively controlled through the lay number of the polyelectrolytes containing opposite charges, and the form of the microcapsules can be controlled through template nucleuses; accordingly, the drug releasing controllability and targeting property can be improved.</description><language>eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20151223&DB=EPODOC&CC=CN&NR=105168181A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20151223&DB=EPODOC&CC=CN&NR=105168181A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MA YUN</creatorcontrib><creatorcontrib>SHANG JINGCHUAN</creatorcontrib><creatorcontrib>WANG JINGWEN</creatorcontrib><creatorcontrib>LI JING</creatorcontrib><creatorcontrib>WANG LAN</creatorcontrib><title>Preparation method for oxymatrine microcapsules</title><description>The invention discloses a preparation method for oxymatrine microcapsules. The method comprises the following steps that silicon dioxide template materials are prepared, and self-assembling is performed layer upon layer by taking poly allyamine hydrochloride and polystyrene sodium sulfonate as positive and negative polyelectrolytes to prepared template microcapsules which are not denucleated; the template microcapsules which are not denucleated are taken, hydrogen fluoride is added to enable SiO2 to be fully dissolved, and centrifugal cleaning is repeatedly performed with a NaCl solution until the pH is 7. According to the preparation method for the oxymatrine microcapsules, the prepared hollow microcapsules are uniform in size and form, the size of the microcapsules can be actively controlled through the lay number of the polyelectrolytes containing opposite charges, and the form of the microcapsules can be controlled through template nucleuses; accordingly, the drug releasing controllability and targeting property can be improved.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNAPKEotSCxKLMnMz1PITS3JyE9RSMsvUsivqMxNLCnKzEtVyM1MLspPTiwoLs1JLeZhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfHOfoYGpoZmFoYWho7GxKgBAH4kK6s</recordid><startdate>20151223</startdate><enddate>20151223</enddate><creator>MA YUN</creator><creator>SHANG JINGCHUAN</creator><creator>WANG JINGWEN</creator><creator>LI JING</creator><creator>WANG LAN</creator><scope>EVB</scope></search><sort><creationdate>20151223</creationdate><title>Preparation method for oxymatrine microcapsules</title><author>MA YUN ; SHANG JINGCHUAN ; WANG JINGWEN ; LI JING ; WANG LAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN105168181A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2015</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>MA YUN</creatorcontrib><creatorcontrib>SHANG JINGCHUAN</creatorcontrib><creatorcontrib>WANG JINGWEN</creatorcontrib><creatorcontrib>LI JING</creatorcontrib><creatorcontrib>WANG LAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MA YUN</au><au>SHANG JINGCHUAN</au><au>WANG JINGWEN</au><au>LI JING</au><au>WANG LAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Preparation method for oxymatrine microcapsules</title><date>2015-12-23</date><risdate>2015</risdate><abstract>The invention discloses a preparation method for oxymatrine microcapsules. The method comprises the following steps that silicon dioxide template materials are prepared, and self-assembling is performed layer upon layer by taking poly allyamine hydrochloride and polystyrene sodium sulfonate as positive and negative polyelectrolytes to prepared template microcapsules which are not denucleated; the template microcapsules which are not denucleated are taken, hydrogen fluoride is added to enable SiO2 to be fully dissolved, and centrifugal cleaning is repeatedly performed with a NaCl solution until the pH is 7. According to the preparation method for the oxymatrine microcapsules, the prepared hollow microcapsules are uniform in size and form, the size of the microcapsules can be actively controlled through the lay number of the polyelectrolytes containing opposite charges, and the form of the microcapsules can be controlled through template nucleuses; accordingly, the drug releasing controllability and targeting property can be improved.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Preparation method for oxymatrine microcapsules |
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