Preparation method for oxymatrine microcapsules

The invention discloses a preparation method for oxymatrine microcapsules. The method comprises the following steps that silicon dioxide template materials are prepared, and self-assembling is performed layer upon layer by taking poly allyamine hydrochloride and polystyrene sodium sulfonate as positive and negative polyelectrolytes to prepared template microcapsules which are not denucleated; the template microcapsules which are not denucleated are taken, hydrogen fluoride is added to enable SiO2 to be fully dissolved, and centrifugal cleaning is repeatedly performed with a NaCl solution until the pH is 7. According to the preparation method for the oxymatrine microcapsules, the prepared hollow microcapsules are uniform in size and form, the size of the microcapsules can be actively controlled through the lay number of the polyelectrolytes containing opposite charges, and the form of the microcapsules can be controlled through template nucleuses; accordingly, the drug releasing controllability and targeting property can be improved.