Establishing method and application of fingerprint of Guanxinning tablets

Establishing method and application of fingerprint of Guanxinning tablets

The invention discloses an establishing method of the fingerprint of Guanxinning tablets. The method comprises the following steps: taking 10 or more batches of Guanxinning tablets, grinding, uniformly mixing, adding distilled water or a methanol-water solution with the volume concentration of 0-100...

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Hauptverfasser: ZHANG WENJIE, CHAI JIANGUO, SHI XIAOPING, SHEN YING, LIN XUJIAN, DAI JINMING
Format: Patent
Sprache:eng
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INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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creator ZHANG WENJIE
CHAI JIANGUO
SHI XIAOPING
SHEN YING
LIN XUJIAN
DAI JINMING
description The invention discloses an establishing method of the fingerprint of Guanxinning tablets. The method comprises the following steps: taking 10 or more batches of Guanxinning tablets, grinding, uniformly mixing, adding distilled water or a methanol-water solution with the volume concentration of 0-100%, carrying out ultrasonic treatment, cooling, filtering, taking the obtained filtrate to obtain a sample solution, carrying out high performance liquid chromatography analysis with a chromatographic column adopting octadecylsilane chemically bonded silica as a filler, carrying out gradient elution by using a phosphoric acid-water solution with the volume concentration of 0.1% as a mobile phase A and acetonitrile as a mobile phase B to obtain the liquid chromatographic spectrum of the different batches of Guanxinning tablets, delivering the obtained liquid chromatographic spectrum into a traditional Chinese medicinal chromatographic fingerprint similarity evaluation system provided by Chinese Pharmacopoeia Commission, setting multi-point correction, and automatically matching to make software automatically generate the standard fingerprint of the Guanxinning tablets. The standard fingerprint of the Guanxinning tablets obtained in the invention can be used to monitor the production technology of Guanxinning tablets, evaluate the quality of the Guanxinning tablets or detect the true and false identification of the Guanxinning tablets.
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subjects INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
title Establishing method and application of fingerprint of Guanxinning tablets
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