Establishing method and application of fingerprint of Guanxinning tablets

The invention discloses an establishing method of the fingerprint of Guanxinning tablets. The method comprises the following steps: taking 10 or more batches of Guanxinning tablets, grinding, uniformly mixing, adding distilled water or a methanol-water solution with the volume concentration of 0-100%, carrying out ultrasonic treatment, cooling, filtering, taking the obtained filtrate to obtain a sample solution, carrying out high performance liquid chromatography analysis with a chromatographic column adopting octadecylsilane chemically bonded silica as a filler, carrying out gradient elution by using a phosphoric acid-water solution with the volume concentration of 0.1% as a mobile phase A and acetonitrile as a mobile phase B to obtain the liquid chromatographic spectrum of the different batches of Guanxinning tablets, delivering the obtained liquid chromatographic spectrum into a traditional Chinese medicinal chromatographic fingerprint similarity evaluation system provided by Chinese Pharmacopoeia Commission, setting multi-point correction, and automatically matching to make software automatically generate the standard fingerprint of the Guanxinning tablets. The standard fingerprint of the Guanxinning tablets obtained in the invention can be used to monitor the production technology of Guanxinning tablets, evaluate the quality of the Guanxinning tablets or detect the true and false identification of the Guanxinning tablets.