Purification method of creatine phosphate sodium

The invention discloses a purification method of creatine phosphate sodium, which comprises the following steps: pretreating a creatine phosphate sodium mother solution with 40-70 vol% ethanol, loading the pretreated creatine phosphate sodium mother solution, eluting creatine by using a 0.02-0.15M electrolyte solution as an eluent, eluting the creatine phosphate sodium by using a 0.2-0.8M electrolyte solution as an eluent, collecting the eluate, crystallizing, and drying to obtain the creatine phosphate sodium. The method is simple, does not need to introduce sulfates or barium, and has high safety. The recovery rate of the prepared creatine phosphate sodium is high and up to 40%, and the purity reaches 99.80%, thereby satisfying the medicinal requirements.