Preparation method of ceftibuten

The invention provides a preparation method of ceftibuten. The preparation method comprises the steps of adding cefaclor nucleus, methyltetrahydrofuran and magnesium powder into a reactor, and reacting until the magnesium powder disappears; then, adding a proper quantity of distilled water, stirring, standing for layering, separating out an organic layer, and drying by using anhydrous magnesium sulfate; after filtering, adding D301 week basic ion exchange resin and 2-(2-carbobenzoxy-aminothiazole-4-yl)-5-carbobenzoxy-2-pentenoic acid, and reacting at a certain temperature for a certain time; after ending the reaction, filtering to remove the week basic ion exchange resin; and then, hydrolyzing to obtain a target product, namely ceftibuten. The method is a novel preparation method of ceftibuten, is high in product yield and purity as well as simple and convenient in operation, is a green and clean production process and is suitable for industrial production on a certain scale; and the cefaclor nucleus is a main product in the company, and a sustainable development technology of the company is to prepare ceftibuten serving as a mainly developed variety in the Tenth Five-year Plan period from the product of the company.