Arylpiperazine derivative II and salts thereof, and preparation method and application thereof

Arylpiperazine derivative II and salts thereof, and preparation method and application thereof

The invention relates to the fields of pharmaceutical chemistry and medicament lead compound discovery, and concretely relates to arylpiperazine derivatives (1) and (2). The invention also discloses a preparation method for the novel arylpiperazine derivatives and application of the arylpiperazine d...

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Bibliographische Detailangaben
Hauptverfasser: YUAN MU, GUO JIEWEN, XU BINGBING, LIANG XUE, CHEN HONG, YANG ZONGLIN, ZHU LIU, YE BIBO, SHAO BINHAO, XU FANG, HUANG JUNJUN
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to the fields of pharmaceutical chemistry and medicament lead compound discovery, and concretely relates to arylpiperazine derivatives (1) and (2). The invention also discloses a preparation method for the novel arylpiperazine derivatives and application of the arylpiperazine derivatives to resist tumors. The compounds are subjected to preliminary pharmacodynamics research and in-vitro antineoplastic experiment, results show that the compounds show relatively good antineoplastic activity and can be used to develop and exploit novel antitumor drugs.