Process For the preparation of HMG-COA reductase inhibitors and intermediates thereof

Process For the preparation of HMG-COA reductase inhibitors and intermediates thereof

The present invention provides an improved process for preparing HMG-CoA reductase inhibitors such as rosuvastatin calcium, fluvastatin sodium, and pitavastatin calcium under a mild condition, using a novel amide-bond-containing compound having R2-N-O-R1 moiety as a key intermediate. And also, the p...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: YI HYUN-JIK, KHOO JA-HEOUK, JU HYUN, LIM JONGUL, JOUNG SANG-SUN, KIM JAE-GYU
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention provides an improved process for preparing HMG-CoA reductase inhibitors such as rosuvastatin calcium, fluvastatin sodium, and pitavastatin calcium under a mild condition, using a novel amide-bond-containing compound having R2-N-O-R1 moiety as a key intermediate. And also, the present invention provides the novel compound, an intermediate useful for the preparation thereof, and a process for the preparation thereof.