Preparing method and application of medicine carrying hydroxyapatite porous microspheres
The invention discloses a preparing method of medicine carrying hydroxyapatite porous microspheres. The preparing method includes the steps that hydroxyapatite is added into a chitosan solution and mixed, the mixed solution is put into an injector, voltage is loaded on a syringe needle of the inject...
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Format: | Patent |
Sprache: | eng |
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Zusammenfassung: | The invention discloses a preparing method of medicine carrying hydroxyapatite porous microspheres. The preparing method includes the steps that hydroxyapatite is added into a chitosan solution and mixed, the mixed solution is put into an injector, voltage is loaded on a syringe needle of the injector, the mixed solution is injected into curing liquid to obtain chitosan/hydroxyapatite microspheres, the chitosan/hydroxyapatite microspheres stand and are filtered, washed and dried to obtain chitosan/hydroxyapatite composite microspheres, the chitosan/hydroxyapatite composite microspheres are heated to 600 DEG C with the temperature rising speed of 2-5 DEG C/min, kept at the temperature for 1-2 h and cooled, and hydroxyapatite porous microspheres are soaked in a chemical solution for 12-24 h, then filtered, frozen with liquid nitrogen and freeze-dried for 24-48 h to obtain the medicine carrying hydroxyapatite porous microspheres. According to the preparing method, no organic solvent or micromolecular toxic substances are added in the production process, the raw materials are easy to obtain, the technology is simple, the production cycle is short, and the problem that the preparing technology of the hydroxyapatite microspheres is complex is solved. |
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