Formation of n-protected bis-3, 6-(4-aminobutyl)-2, 5-diketopiperazine through a cyclic alpha-n-protected amino ester

Formation of n-protected bis-3, 6-(4-aminobutyl)-2, 5-diketopiperazine through a cyclic alpha-n-protected amino ester

A method for the synthesis of N-protected 3, 6-aminoalkyl-2, 5-diketopiperazines is provided. The method includes obtaining a cyclic a-N protected active amino ester and adding it to a mixture of an amine catalyst in an organic solvent.

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Bibliographische Detailangaben
Hauptverfasser: FREEMAN JOHN J, PHANSTIEL OTTO, KRAFT KELLY SULLIVAN, BAY WILLIAM ELLIOT
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A method for the synthesis of N-protected 3, 6-aminoalkyl-2, 5-diketopiperazines is provided. The method includes obtaining a cyclic a-N protected active amino ester and adding it to a mixture of an amine catalyst in an organic solvent.