Aryl piperazine derivatives (I), salts, preparation method, and applications thereof

The invention relates to the fields of pharmaceutical chemistry and lead compounds in drug discovery, and specifically relates to aryl piperazine derivatives (I). In the formula (I), the definitions of R1 to R5 have been represented in the description. The invention also discloses a preparation meth...

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Hauptverfasser:	YUAN MU, GUO JIEWEN, XU BINGBING, LIANG XUE, CHEN HONG, YANG ZONGLIN, ZHU LIU, YE BIBO, SHAO BINHAO, XU FANG, HUANG JUNJUN
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Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	YUAN MU GUO JIEWEN XU BINGBING LIANG XUE CHEN HONG YANG ZONGLIN ZHU LIU YE BIBO SHAO BINHAO XU FANG HUANG JUNJUN
description	The invention relates to the fields of pharmaceutical chemistry and lead compounds in drug discovery, and specifically relates to aryl piperazine derivatives (I). In the formula (I), the definitions of R1 to R5 have been represented in the description. The invention also discloses a preparation method of the aryl piperazine derivatives (1) and anti-tumor applications of the novel derivatives. The provided compounds have been applied to primary pharmacodynamic study and in-vitro antitumor experiments. The results show that some compounds have good antitumor activity and can be used to develop novel antitumor drugs.
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title	Aryl piperazine derivatives (I), salts, preparation method, and applications thereof
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